If together, ATM kinase and p53 decide that the DNA is beyond repair, the cell will undergo apoptosis as orchestrated by p53.
You had one ‘perfect’ copy of DNA in your chromosomes when you were a single cell fertilized ege. Since then, each copy has made successive generations progressively worse
This article from JAMA argues that the 4.8% cancer mortality rate for large and long-lived elephants compares favorably to our 25% rate because unlike our two copies of the p53 (watchman of the genome) gene, they have up to 40 copies.
“The time has come to seriously ask whether antioxidant use more likely causes than prevents cancer,” Dr. Watson said. Nutritional intervention trials have shown no obvious effectiveness in preventing cancer or in lengthening lifespan, and, “in fact, they seem to slightly shorten the lives of those who take them.”
Salk institute researcher, Jan Karisider shows that cancer cells can be induced into cell crisis and death not just slowly by telomere erosion but immediately via the p53 “watchman of the genome”
Simply stated, telomerase is neither pro nor anti-tumorigenic any more than a foot or a brake pedal cause car accidents while driving down a mountain. Telomerase, like a driver’s foot, prevents carcinogenesis by speeding up or slowing down the car.
DISCLAIMER: This website is for educational purposes only and is not for advertising. Telomerase activators and nanovesicles are not FDA-approved to prevent or treat any disease and anecdotes are not scientific proof of efficacy. All patients were treated in the context of a fully informed and legally-protected patient physician relationship.
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Exosomes and TA-65 are not FDA-approved to prevent or treat any illness
