General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition.  Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.

Exosomes 13: Microneedling my Mom with Exosomes

At the exosome seminars that I’ve attended, I was astonished by the before and after pictures as well as the live demonstration of microneedling with exosomes. The so-called “vampire facials” that celebrities use is a microneedling+platelet rich plasma technique that has the body’s inflammation to leverage but what if you cells are old and your inflammatory response is less than vigorous? Microneedling with exosomes can introduce growth factors and cellular/collagen regrowth in a way that a vampire facial cannot and the MSC exosomes are anti-inflammatory leading to much less post-procedure “down time”.

My mom, aka my 82-yo faithful guinea pig, volunteered to have the procedure done last week and she is very happy with the results. For those unfamiliar with the procedure, a Dr. Pen A7 cartridge has 36 very fine needles (34 guage) that puncture the epidermis to a precise adjustable depth of 0.25-2mm up to 1300 times a second. The skin quickly closes but for a few brief minutes, a direct channel exists to introduce MSC exosomes into the deeper layers of the epidermis and dermis where they reprogram the fibroblasts and epithelial cells.

The procedure only requires 1cc of exosomes but in this case, I used 2cc and gave mom her 4th intranasal injection with the remainder. The skin is cleansed and then a topical cream of benzocaine/lidocaine/tetracaine is applied under cellophane for 20 minutes. The procedure was painless. The picture below shows the cellophane and mom’s face immediately after (note how relatively bloodless the procedure is). The pads are because we did her neck and décolleté as well.

The picture below shows mom’s face prior to the procedure, just one day after (note minimal swelling, redness, or trauma), and four days after. The lighting is better and she is wearing makeup but there is no filter and she claims the face is smoother, wrinkles faded, and pores are smaller.

If you are on the fence about trying exosomes then maybe this will sway you. We can use 1-2cc on your facial rejuvenation and then the rest IV, intranasal, or into a troubled joint with ultrasound guidance.

They say it’s better to look good than to feel good but why not do both!  Please contact me if you would like to schedule an appointment for exosome therapy and microneedling. This includes you too, guys!

To learn more about the proof of this technique, read this article where they used a randomized, double-blinded, split face study design to show efficacy of exosomes versus placebo when combined with microneedling. In this study they called it “conditioned media” but it is really just exosomes that they are using (from embryonic stem cells in this case).

https://www.researchgate.net/publication/267043397_Efficacy_of_Microneedling_Plus_Human_Stem_Cell_Conditioned_Medium_for_Skin_Rejuvenation_A_Randomized_Controlled_Blinded_Split-Face_Study

Feel free to bookmark the following link to have all my exosomes videos at your fingertips!

www.tinyurl.com/exosomesvideos

Archived exosome blogs….Please read them all. 

N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.

https://www.rechargebiomedical.com/exosomes-1-the-journey-begins/

I still have voluntary ASMR. Mom’s arthritis is greatly improved. 

https://www.rechargebiomedical.com/exosomes-2-not-inert/

I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.

https://www.rechargebiomedical.com/exosomes-3-a-case-of-brain-and-neck-trauma/

A case of whiplash and traumatic brain injury improved after exosome use.

https://www.rechargebiomedical.com/exosomes-4-back-on-the-treadmill-again/

After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)

https://www.rechargebiomedical.com/exosomes-5-clinical-medicine-is-bittersweet/

In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.  

https://www.rechargebiomedical.com/exosomes-blog-6-healing-takes-time/

Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.

https://www.rechargebiomedical.com/exosomes-blog-7-nerve-pain-gone/

A patient after dental exosome injection becomes pain free after 4 years of suffering.

http://www.rechargebiomedical.com/exosomes-blog-8-disinformation-or-bad-science/

I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.

https://www.rechargebiomedical.com/exosomes-blog-9-watch-all-my-exosome-videos/

A nine-part comprehensive explanation of exosomes.

https://www.rechargebiomedical.com/interviews-with-exosome-experts-posted/

I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes

https://www.rechargebiomedical.com/exosomes-blog-11-deb-bs-knees-are-improving

66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.

https://www.rechargebiomedical.com/80-yo-doug-ran-121-miles-in-6-days/

80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.

https://www.rechargebiomedical.com/exosome-blog-13-microneedling-my-mom-with-exosomes/

My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.

https://www.rechargebiomedical.com/exosome-blog-14-the-shoulder/

54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection

https://www.rechargebiomedical.com/exosomes-blog-15-face-blindness/

48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently

https://www.rechargebiomedical.com/exosomes-blog-16-lecture-in-hawaii/

I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications. 

https://www.rechargebiomedical.com/exosomes-blog-17-reading-is-fundamental

Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy

https://www.rechargebiomedical.com/exosomes-blog-18-dental-health-improved

Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy

https://www.rechargebiomedical.com/exosomes-19-chakra-balancing-with-exosomes/

We discuss the notion of energy centers known as chakras and the fact that we are electrical beings

https://www.rechargebiomedical.com/exosomes-blog-20-seborrheoic-dermatitis/

A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.

https://www.rechargebiomedical.com/exosomes-blog-21-bias-is-unavoidable/

I explain how poor we are at assessing change and how attribution and recall bias play important roles

https://www.rechargebiomedical.com/exosomes-22-badpress/

In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.

https://www.rechargebiomedical.com/exosomes-blog-23-stasis-dermatitis

I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation

https://www.rechargebiomedical.com/exosomes-blog-24-how-long-do-exosomes-last

I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.

https://www.rechargebiomedical.com/exosomes-blog-25-knee-treatments/

I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.

https://www.rechargebiomedical.com/exosomes-blog-26-the-placebo-effect/

I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.

https://www.rechargebiomedical.com/exosomes-27-soft-signs-of-exosome-actions/

Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).

https://www.rechargebiomedical.com/exosomes-28-varicose-veins/

Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.

https://www.rechargebiomedical.com/exosomes-29-are-exosomes-smart/

I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.

https://www.rechargebiomedical.com/exosomes-30-real-exosomes-patients/

I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.

https://www.rechargebiomedical.com/exosomes-blog-31-leg-swelling/

I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.

https://www.rechargebiomedical.com/exosomes-32-nerve-regeneration

We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.