Category: Telomere erosion

Real patient experiences

Alzheimer’s Disease causally linked to shorter telomeres

According to this study published by the Karolinska Institute in Stockholm in JAMA Neurology this week, there is a statistical association between Alzheimer’s disease and shorter telomeres via the single nucleotide polymorphisms associated with telomere shortening.

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Premature aging linked to telomeres – cure found

they could “cure” their HGPS mouse model by two two things. In figure C, they added telomerase activity. In figure D, they added a little extra LAP2α.

There are many who feel that telomeres and telomerase are not centrally related to aging. This study shows that for at least this classic model of premature aging, Sutton’ Law still applies.

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What can a painting teach us about why we THINK we age?

In the Picasso version, we have the closest to a pure expression sans our mundane subjectivity. There are shapes and colors but the ability to project morality and order upon it weakened. It is this final, morally and evolutionarily-bereft version that we find the greatest truth of aging.

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70 years since Hiroshima Atomic Bomb detonated- is radiation good or bad?

The effects of high level exposure to ionizing radiation are devastating and well-documented. At a level of over 6 grays, the mortality approaches 100% from genetic damage to so many stem cells that you cannot recover.

What is interesting is that a lower level of radiation is actually healthy! This is known as the radiation hormesis phenomenon.

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Are your naïve T-cells more like Martin Riggs or Roger Murtaugh?

Interestingly, Naive T-Cells can be further subdivided into “good cops” and “bad cops” as in Lethal Weapon. The good ones, present in younger, healthier individuals, are naive and ready to go, like Bat-guano crazy Mel Gibson’s Martin Riggs character. The bad ones are like Danny Glover’s character, Roger Murtaugh, hiking up their pants and counting the days to retirement while muttering “I’m too old for this $h!t”

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